{"id":23947,"date":"2025-05-02T18:36:31","date_gmt":"2025-05-02T16:36:31","guid":{"rendered":"https:\/\/janvier-labs.com\/?page_id=23947"},"modified":"2025-05-02T19:32:44","modified_gmt":"2025-05-02T17:32:44","slug":"knock-in","status":"publish","type":"page","link":"https:\/\/janvier-labs.com\/en\/humanized-models\/knock-in\/","title":{"rendered":"Knock-in humanized"},"content":{"rendered":"
\n \"\"\n

Accueil<\/a><\/span><\/span><\/p>

\n

Knock-in humanized models<\/h1>\n

The reference to assess compounds that specifically target human proteins<\/h2>\n \n
\n \n\t\t\n\t\n\t\n\n <\/span>\n\t<\/form> <\/div>\n<\/section>\n\n\n
<\/div>\n\n\n\n

Accelerate your development program
with a knock-in humanized model<\/h2>\n\n\n\n
<\/div>\n\n\n\n

Knock-in humanized mouse models are fully immunocompetent mice in which one or more mouse genes have been replaced by their human orthologs.<\/p>\n\n\n\n

This enables the assessment of compounds that specifically target human proteins.<\/p>\n\n\n\n

These models are also suitable for transplanting tumor cells of mouse origin to generate syngeneic tumor models.<\/p>\n\n\n\n

<\/p>\n\n\n

\n

Selection of Knock-in humanized models<\/h2>\n
\n
\n
\n \"image<\/a>\n <\/div>\n
\n \n

B6 hPD-1 Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n \n Oncology<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

B6 hPD-L1 Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n \n Oncology<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

B6 hCTLA-4 Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n \n Oncology<\/span>\n <\/a>\n \n Auto-immune diseases<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

B6 hPD-1\/hPD-L1 Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n \n Oncology<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

B6 hPD-1\/hCTLA-4 Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n \n Oncology<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

B6 hCD28 Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n \n Oncology<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

B6 hCD19 Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n \n Oncology<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

B6 hFcRN Mouse<\/p>\n <\/a>\n \n Auto-immune diseases<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

B6 hCD3EDG Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n \n Oncology<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n \n \n \n \n \n <\/div>\n<\/section>\n\n\n

<\/div>\n\n\n\n

<\/h2>\n","protected":false},"excerpt":{"rendered":"

Accelerate your development programwith a knock-in humanized model Knock-in humanized mouse models are fully immunocompetent mice in which one or more mouse genes have been replaced by their human orthologs. This enables the assessment of compounds that specifically target human proteins. These models are also suitable for transplanting tumor cells of mouse origin to generate […]<\/p>\n","protected":false},"author":21,"featured_media":0,"parent":12277,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/immuno-onco.php","meta":{"_acf_changed":false,"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","footnotes":""},"class_list":["post-23947","page","type-page","status-publish","hentry","entry"],"acf":[],"yoast_head":"\nKnock-in humanized - Janvier Labs<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/janvier-labs.com\/en\/humanized-models\/knock-in\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Knock-in humanized - Janvier Labs\" \/>\n<meta property=\"og:description\" content=\"Accelerate your development programwith a knock-in humanized model Knock-in humanized mouse models are fully immunocompetent mice in which one or more mouse genes have been replaced by their human orthologs. This enables the assessment of compounds that specifically target human proteins. These models are also suitable for transplanting tumor cells of mouse origin to generate […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/janvier-labs.com\/en\/humanized-models\/knock-in\/\" \/>\n<meta property=\"og:site_name\" content=\"Janvier Labs\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-02T17:32:44+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/humanized-models\\\/knock-in\\\/\",\"url\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/humanized-models\\\/knock-in\\\/\",\"name\":\"Knock-in humanized - Janvier Labs\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/#website\"},\"datePublished\":\"2025-05-02T16:36:31+00:00\",\"dateModified\":\"2025-05-02T17:32:44+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/humanized-models\\\/knock-in\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/janvier-labs.com\\\/en\\\/humanized-models\\\/knock-in\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/humanized-models\\\/knock-in\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Humanized models\",\"item\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/humanized-models\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Knock-in humanized\",\"item\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/humanized-models\\\/knock-in\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Knock-in humanized\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/\",\"name\":\"Janvier Labs\",\"description\":\"Expertise in Rodent Research Models\",\"publisher\":{\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/#organization\",\"name\":\"Janvier Labs\",\"url\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/janvier-labs.com\\\/wp-content\\\/uploads\\\/Logo-JL-Couleur-JANVIER-GROUP-500px-smallerJG.webp\",\"contentUrl\":\"https:\\\/\\\/janvier-labs.com\\\/wp-content\\\/uploads\\\/Logo-JL-Couleur-JANVIER-GROUP-500px-smallerJG.webp\",\"width\":500,\"height\":279,\"caption\":\"Janvier Labs\"},\"image\":{\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Knock-in humanized - Janvier Labs","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/janvier-labs.com\/en\/humanized-models\/knock-in\/","og_locale":"en_US","og_type":"article","og_title":"Knock-in humanized - Janvier Labs","og_description":"Accelerate your development programwith a knock-in humanized model Knock-in humanized mouse models are fully immunocompetent mice in which one or more mouse genes have been replaced by their human orthologs. This enables the assessment of compounds that specifically target human proteins. These models are also suitable for transplanting tumor cells of mouse origin to generate […]","og_url":"https:\/\/janvier-labs.com\/en\/humanized-models\/knock-in\/","og_site_name":"Janvier Labs","article_modified_time":"2025-05-02T17:32:44+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/janvier-labs.com\/en\/humanized-models\/knock-in\/","url":"https:\/\/janvier-labs.com\/en\/humanized-models\/knock-in\/","name":"Knock-in humanized - Janvier Labs","isPartOf":{"@id":"https:\/\/janvier-labs.com\/en\/#website"},"datePublished":"2025-05-02T16:36:31+00:00","dateModified":"2025-05-02T17:32:44+00:00","breadcrumb":{"@id":"https:\/\/janvier-labs.com\/en\/humanized-models\/knock-in\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/janvier-labs.com\/en\/humanized-models\/knock-in\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/janvier-labs.com\/en\/humanized-models\/knock-in\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/janvier-labs.com\/en\/"},{"@type":"ListItem","position":2,"name":"Humanized models","item":"https:\/\/janvier-labs.com\/en\/humanized-models\/"},{"@type":"ListItem","position":3,"name":"Knock-in humanized","item":"https:\/\/janvier-labs.com\/en\/humanized-models\/knock-in\/"},{"@type":"ListItem","position":4,"name":"Knock-in humanized"}]},{"@type":"WebSite","@id":"https:\/\/janvier-labs.com\/en\/#website","url":"https:\/\/janvier-labs.com\/en\/","name":"Janvier Labs","description":"Expertise in Rodent Research Models","publisher":{"@id":"https:\/\/janvier-labs.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/janvier-labs.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/janvier-labs.com\/en\/#organization","name":"Janvier Labs","url":"https:\/\/janvier-labs.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/janvier-labs.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/janvier-labs.com\/wp-content\/uploads\/Logo-JL-Couleur-JANVIER-GROUP-500px-smallerJG.webp","contentUrl":"https:\/\/janvier-labs.com\/wp-content\/uploads\/Logo-JL-Couleur-JANVIER-GROUP-500px-smallerJG.webp","width":500,"height":279,"caption":"Janvier Labs"},"image":{"@id":"https:\/\/janvier-labs.com\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/janvier-labs.com\/en\/wp-json\/wp\/v2\/pages\/23947","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/janvier-labs.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/janvier-labs.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/janvier-labs.com\/en\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"https:\/\/janvier-labs.com\/en\/wp-json\/wp\/v2\/comments?post=23947"}],"version-history":[{"count":7,"href":"https:\/\/janvier-labs.com\/en\/wp-json\/wp\/v2\/pages\/23947\/revisions"}],"predecessor-version":[{"id":24016,"href":"https:\/\/janvier-labs.com\/en\/wp-json\/wp\/v2\/pages\/23947\/revisions\/24016"}],"up":[{"embeddable":true,"href":"https:\/\/janvier-labs.com\/en\/wp-json\/wp\/v2\/pages\/12277"}],"wp:attachment":[{"href":"https:\/\/janvier-labs.com\/en\/wp-json\/wp\/v2\/media?parent=23947"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}