{"id":23949,"date":"2025-05-02T19:17:47","date_gmt":"2025-05-02T17:17:47","guid":{"rendered":"https:\/\/janvier-labs.com\/?page_id=23949"},"modified":"2025-06-20T12:54:45","modified_gmt":"2025-06-20T10:54:45","slug":"humanized-immune-system-his-models","status":"publish","type":"page","link":"https:\/\/janvier-labs.com\/en\/humanized-models\/humanized-immune-system-his-models\/","title":{"rendered":"Humanized Immune System (HIS)"},"content":{"rendered":"
\n \"\"\n

Accueil<\/a><\/span><\/span><\/p>

\n

Humanized Immune System (HIS) models<\/h1>\n

The reference for immunotherapeutics development<\/h2>\n \n
\n \n\t\t\n\t\n\t\n\n <\/span>\n\t<\/form> <\/div>\n<\/section>\n\n\n
<\/div>\n\n\n\n

Accelerate your development program
with a HIS model<\/h2>\n\n\n\n
<\/div>\n\n\n\n

The rise of research to develop treatments in oncology, immunology and infectious diseases is leading to a rapid
increase in the demand for humanized mouse models. JANVIER LABS has developed the NXG-HIS mouse, a strain that
completes our range of fully characterized immunodeficient models, providing a predictive preclinical model, in
particular for the evaluation of immunotherapies.
<\/p>\n\n\n\n

The NXG-HIS mouse is a mouse model with a human immune system, here by treatment with Busulfan and
engraftment of human CD34 cells. This model is particularly relevant for preclinical studies, especially for the evaluation
of a multitude human molecules and innovative therapeutic targets.<\/p>\n\n\n

\n

Our HIS models<\/h2>\n
\n
\n
\n \"image<\/a>\n <\/div>\n
\n \n

NXG HSPC Mouse<\/p>\n <\/a>\n \n Physiology – Physiopathology<\/span>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n \n Infectious diseases<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

NRG HSPC Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n \n Infectious diseases<\/span>\n <\/a>\n \n Oncology<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

NRG cKit HSPC Mouse<\/p>\n <\/a>\n \n Oncology<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

BRGS A2DR2 HSPC Mouse<\/p>\n <\/a>\n \n Infectious diseases<\/span>\n <\/a>\n \n Oncology<\/span>\n <\/a>\n \n Auto-immune diseases<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

BRGS TSLP HSPC Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n \n Infectious diseases<\/span>\n <\/a>\n \n Oncology<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

NXG ILIX HSPC Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n \n Oncology<\/span>\n <\/a>\n \n Immunotherapy<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

NXG hIL-15 HSPC Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n \n Immunotherapy<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

NXG hIL-2 HSPC Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

NXG hIL6\/hIL6R HSPC Mouse<\/p>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

NXG HLA-A*02:01 HSPC Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

NXG PBMC Mouse<\/p>\n <\/a>\n \n Immunology<\/span>\n <\/a>\n \n Infectious diseases<\/span>\n <\/a>\n \n Oncology<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n

\n
\n \"image<\/a>\n <\/div>\n
\n \n

NXG B2M PBMC Mouse<\/p>\n <\/a>\n \n Humanization<\/span>\n <\/a>\n <\/div>\n \n <\/article>\n \n \n \n \n \n \n <\/div>\n<\/section>\n\n\n

<\/div>\n\n\n\n

NXG, a perfect model for the humanization <\/strong>
of the immune system<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n\n

The NXG original model for the creation of the NXG-HIS is a genetically modified strain (GEMM) obtained by
homologous recombination (IL2rg), in NOD fund and presenting the SCID mutation of interest.
The NXG mouse is a JANVIER LABS proprietary model, free to use and genetically characterized (its severe
immunodeficiency makes it a perfect model for the humanization of its immune system).<\/p>\n\n\n\n

<\/div>\n\n\n
\n
\n

Janvier Labs supports you for your research in immunology and oncology<\/h2>\n

<\/p>\n

\n
\n \"\"\n
\n

Get access to all our models<\/h3>\n

Janvier Labs provides a comprehensive range of all the available models. Make your research easier and save time to make your choice.<\/p>\n

Download the catalog<\/p>\u3009<\/span><\/a>\n <\/div>\n <\/div>\n

\n \"\"\n
\n

Did you find your model?<\/h3>\n

Have your model created by our experts. We are working with the Center of Immunophenomics in Marseille to give access to a comprehensive and integrated offering, with options for characterization, cryopreservation and breeding to meet your requirements.<\/p>\n

Contact us<\/p>\u3009<\/span><\/a>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/section>\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Accelerate your development program with a HIS model The rise of research to develop treatments in oncology, immunology and infectious diseases is leading to a rapid increase in the demand for humanized mouse models. JANVIER LABS has developed the NXG-HIS mouse, a strain that completes our range of fully characterized immunodeficient models, providing a predictive […]<\/p>\n","protected":false},"author":21,"featured_media":0,"parent":12277,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/immuno-onco.php","meta":{"_acf_changed":false,"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","footnotes":""},"class_list":["post-23949","page","type-page","status-publish","hentry","entry"],"acf":[],"yoast_head":"\nHumanized Immune System (HIS) - Janvier Labs<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/janvier-labs.com\/en\/humanized-models\/humanized-immune-system-his-models\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Humanized Immune System (HIS) - Janvier Labs\" \/>\n<meta property=\"og:description\" content=\"Accelerate your development program with a HIS model The rise of research to develop treatments in oncology, immunology and infectious diseases is leading to a rapid increase in the demand for humanized mouse models. 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