{"id":15606,"date":"2023-02-02T13:19:37","date_gmt":"2023-02-02T12:19:37","guid":{"rendered":"https:\/\/janvier-labs.com\/?p=15606"},"modified":"2023-02-02T16:29:07","modified_gmt":"2023-02-02T15:29:07","slug":"discover-the-innovative-brgs-a2dr2-mouse-model","status":"publish","type":"post","link":"https:\/\/janvier-labs.com\/en\/2023\/02\/02\/discover-the-innovative-brgs-a2dr2-mouse-model\/","title":{"rendered":"Discover the innovative BRGS A2DR2 mouse model"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>The new BRGS A2DR2 model is ideal to\u00a0study human immunity.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>These next-generation<\/strong>&nbsp;humanized mice expressing HLA transgenes exhibit improved human immune reconstitution and functionality, and better recapitulate human diseases.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The BRGS A2DR2 is particularly relevant to decipher<strong>&nbsp;the&nbsp;drug candidates mode of action and gives an opportunity to precisely evaluate<\/strong>&nbsp;<strong>new therapies<\/strong>&nbsp;in the fields of oncology, immunology, inflammation, auto-immunity and infectious diseases.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The BRGS A2DR2 or Balb\/c Rag2 \u03b3c Sirpa is a<strong>&nbsp;severely immunodeficient inbred model&nbsp;<\/strong>on a Balb\/c background) and carries two Knock Out (KO) genetic mutations. The combination of these two mutations,&nbsp;<em>Rag2T&nbsp;<\/em>and<em>&nbsp;IL2rgTm1<\/em>, induces a severe immunodeficiency with absence of T, B and NK lymphocyte compartments.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Associated to the Sirpa (NOD Background) gene, it increases xenotransplantation permissivity.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The BRGS A2DR2 model allows preclinical studies with prolonged timelines, in particular efficacy studies with human CDX and PDX xenografts.<\/p>\n\n\n\n<h2 class=\"has-vivid-cyan-blue-color has-text-color has-large-font-size wp-block-heading\">Why choose the BRGS A2DR2 mouse?<\/h2>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" width=\"350\" height=\"223\" data-src=\"https:\/\/janvier-labs.com\/wp-content\/uploads\/Image2-2.jpg\" alt=\"\" class=\"wp-image-15590 size-full lazyload\" data-srcset=\"https:\/\/janvier-labs.com\/wp-content\/uploads\/Image2-2.jpg 350w, https:\/\/janvier-labs.com\/wp-content\/uploads\/Image2-2-300x191.jpg 300w\" data-sizes=\"(max-width: 350px) 100vw, 350px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 350px; --smush-placeholder-aspect-ratio: 350\/223;\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"wp-block-paragraph\">BRGSirpaNOD animals were generated and then backcrossed (speed congenics) to BALB\/c(n) background for six generations.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Human HLA molecules: HLA-A*02-HHD class I and HLA-DRB1*15 class II transgenic mice (B6 background), have been then backrossed (&gt;10 generations) to the Balb\/c Rag2 \u03b3c Sirpa strain (BRGS) , to create the BRGS A2DR2 Strain.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The BRGS A2DR2 strain carries the transgenes expressing the human HLA molecules A2 and DR2.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe48e5de wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/janvier-labs.com\/en\/fiche_produit\/2_brgs_a2dr2\/\" target=\"_blank\" rel=\"noreferrer noopener\">Learn more<\/a><\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"has-vivid-cyan-blue-color has-text-color has-large-font-size wp-block-heading\">Article of interest<\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><div class=\"wpcp-wp-lightbox-host wpcp-advanced-image-lightbox-icon-hover\"><a class=\"wpcp-wp-lightbox-image-link\" href=\"https:\/\/janvier-labs.com\/wp-content\/uploads\/publi.jpg\" data-wpcp-wp-lb-image=\"1\"><img decoding=\"async\" width=\"839\" height=\"490\" data-src=\"https:\/\/janvier-labs.com\/wp-content\/uploads\/publi.jpg\" alt=\"\" class=\"wp-image-15586 lazyload\" data-srcset=\"https:\/\/janvier-labs.com\/wp-content\/uploads\/publi.jpg 839w, https:\/\/janvier-labs.com\/wp-content\/uploads\/publi-300x175.jpg 300w, https:\/\/janvier-labs.com\/wp-content\/uploads\/publi-768x449.jpg 768w\" data-sizes=\"(max-width: 839px) 100vw, 839px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 839px; --smush-placeholder-aspect-ratio: 839\/490;\" \/><\/a><a href=\"https:\/\/janvier-labs.com\/wp-content\/uploads\/publi.jpg\" data-fancybox=\"wpcp-wp-img-15587\" class=\"wpcp-lightbox-trigger wpcp-advanced-image-lightbox-icon wpcp-position-top-right wpcp-advanced-image-lightbox-icon-hover wpcp-global-lightbox-icon wpcp-lightbox-icon--global wpcp-lb-icon-style-default\" data-wpcp-lb-icon-source=\"global\" aria-label=\"Open image in lightbox\" data-thumb-src=\"https:\/\/janvier-labs.com\/wp-content\/uploads\/publi-300x175.jpg\" data-wpcp-lb-single=\"1\"><span class=\"wpcp-icon-container\"><svg viewBox=\"0 0 20 20\" fill=\"currentColor\"><path d=\"M17.6585 16.025L14.2437 12.6198C15.1716 11.3338 15.6121 9.7613 15.4871 8.1819C15.362 6.60251 14.6795 5.11847 13.5607 3.99351C12.936 3.36206 12.1916 2.86066 11.3709 2.51845C10.5502 2.17623 9.66952 2 8.77995 2C7.89039 2 7.00969 2.17623 6.18899 2.51845C5.36829 2.86066 4.62395 3.36206 3.99919 3.99351C3.36594 4.61649 2.86312 5.35871 2.51992 6.17708C2.17673 6.99545 2 7.87365 2 8.76068C2 9.64772 2.17673 10.5259 2.51992 11.3443C2.86312 12.1627 3.36594 12.9049 3.99919 13.5279C5.11957 14.6901 6.62279 15.4103 8.23285 15.5562C9.84291 15.7022 11.4517 15.2641 12.7639 14.3224L16.1788 17.7275C16.3849 17.9034 16.6473 18 16.9186 18C17.1899 18 17.4523 17.9034 17.6585 17.7275C18.1138 17.16 18.1138 16.5925 17.6585 16.025ZM5.59278 12.0523C5.16258 11.6298 4.82094 11.1263 4.58774 10.5709C4.35455 10.0156 4.23446 9.41951 4.23446 8.81744C4.23446 8.21536 4.35455 7.6193 4.58774 7.06394C4.82094 6.50859 5.16258 6.00503 5.59278 5.58257C6.01644 5.15359 6.52144 4.81292 7.07838 4.58039C7.63532 4.34786 8.23308 4.22811 8.83687 4.22811C9.44066 4.22811 10.0384 4.34786 10.5954 4.58039C11.1523 4.81292 11.6573 5.15359 12.081 5.58257C12.5112 6.00503 12.8528 6.50859 13.086 7.06394C13.3192 7.6193 13.4393 8.21536 13.4393 8.81744C13.4393 9.41951 13.3192 10.0156 13.086 10.5709C12.8528 11.1263 12.5112 11.6298 12.081 12.0523C11.6573 12.4813 11.1523 12.822 10.5954 13.0545C10.0384 13.287 9.44066 13.4068 8.83687 13.4068C8.23308 13.4068 7.63532 13.287 7.07838 13.0545C6.52144 12.822 6.01644 12.4813 5.59278 12.0523Z\" \/><\/svg><\/span><\/a><\/div><\/figure>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe48e5de wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/janvier-labs.com\/wp-content\/uploads\/Eur-J-Immunol-2019-Masse%E2%80%90Ranson-Accelerated-thymopoiesis-and-improved-T%E2%80%90cell-responses-in-HLA%E2%80%90A2-%E2%80%90DR2-transgenic-1.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Access to the publication<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>The new BRGS A2DR2 model is ideal to\u00a0study human immunity. These next-generation&nbsp;humanized mice expressing HLA transgenes exhibit improved human immune reconstitution and functionality, and better recapitulate human diseases. The BRGS A2DR2 is particularly relevant to decipher&nbsp;the&nbsp;drug candidates mode of action and gives an opportunity to precisely evaluate&nbsp;new therapies&nbsp;in the fields of oncology, immunology, inflammation, auto-immunity [&hellip;]<\/p>\n","protected":false},"author":14,"featured_media":15630,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"ocean_front_end_style_editor":"no","ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","ocean_post_oembed":"","ocean_post_self_hosted_media":"","ocean_post_video_embed":"","ocean_link_format":"","ocean_link_format_target":"self","ocean_quote_format":"","ocean_quote_format_link":"post","ocean_gallery_link_images":"off","ocean_gallery_id":[],"footnotes":""},"categories":[219],"tags":[],"class_list":["post-15606","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en","entry","has-media"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Discover the innovative BRGS A2DR2 mouse model - Janvier Labs<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/janvier-labs.com\/en\/2023\/02\/02\/discover-the-innovative-brgs-a2dr2-mouse-model\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Discover the innovative BRGS A2DR2 mouse model - Janvier Labs\" \/>\n<meta property=\"og:description\" content=\"The new BRGS A2DR2 model is ideal to\u00a0study human immunity. These next-generation&nbsp;humanized mice expressing HLA transgenes exhibit improved human immune reconstitution and functionality, and better recapitulate human diseases. The BRGS A2DR2 is particularly relevant to decipher&nbsp;the&nbsp;drug candidates mode of action and gives an opportunity to precisely evaluate&nbsp;new therapies&nbsp;in the fields of oncology, immunology, inflammation, auto-immunity [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/janvier-labs.com\/en\/2023\/02\/02\/discover-the-innovative-brgs-a2dr2-mouse-model\/\" \/>\n<meta property=\"og:site_name\" content=\"Janvier Labs\" \/>\n<meta property=\"article:published_time\" content=\"2023-02-02T12:19:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-02-02T15:29:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/janvier-labs.com\/wp-content\/uploads\/A2DR2_vignette2-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"391\" \/>\n\t<meta property=\"og:image:height\" content=\"200\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Coralie TAURINES\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Coralie TAURINES\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/2023\\\/02\\\/02\\\/discover-the-innovative-brgs-a2dr2-mouse-model\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/2023\\\/02\\\/02\\\/discover-the-innovative-brgs-a2dr2-mouse-model\\\/\"},\"author\":{\"name\":\"Coralie TAURINES\",\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/#\\\/schema\\\/person\\\/5a83d3455bfabd45d104a9a5904bf152\"},\"headline\":\"Discover the innovative BRGS A2DR2 mouse model\",\"datePublished\":\"2023-02-02T12:19:37+00:00\",\"dateModified\":\"2023-02-02T15:29:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/2023\\\/02\\\/02\\\/discover-the-innovative-brgs-a2dr2-mouse-model\\\/\"},\"wordCount\":255,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/2023\\\/02\\\/02\\\/discover-the-innovative-brgs-a2dr2-mouse-model\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/janvier-labs.com\\\/wp-content\\\/uploads\\\/A2DR2_vignette2-1.jpg\",\"articleSection\":[\"news\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/janvier-labs.com\\\/en\\\/2023\\\/02\\\/02\\\/discover-the-innovative-brgs-a2dr2-mouse-model\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/2023\\\/02\\\/02\\\/discover-the-innovative-brgs-a2dr2-mouse-model\\\/\",\"url\":\"https:\\\/\\\/janvier-labs.com\\\/en\\\/2023\\\/02\\\/02\\\/discover-the-innovative-brgs-a2dr2-mouse-model\\\/\",\"name\":\"Discover the innovative BRGS A2DR2 mouse model - 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