Research models

List of models

Nomenclature: C57BL/6NRj

Type: Inbred mouse
Colour and related genotype: Black mouse, a (a/a) non agouti - MHC: Haplotype H2b
Origin: National Institutes of Health (USA) - 1999
Breeding: Good breeder but quite difficult to rear (sensitive to theenvironment). Cannibalism with its pups.

Fields of research

  • Cardiovascular research: atherosclerosis
  • Hematology
  • Immunology and inflammation
  • Infections
  • Metabolism: obesity, diabetes, hyperglycemia, insulin resistance
  • Neurobiology and neuro-sensorial research
  • Oncology
  • Ophthalmology and retina degeneration
  • Toxicology

Description of our model

This strain was created by C.C. LITTLE, in 1921, from Miss Abbie LATHROP’s stock. The Jackson Laboratory’s colony was divided in two sub-strains before 1937, resulting in the C57BL/6 and the C57BL/10 strains. The C57BL/6 strain was brought to The Jackson Laboratory in 1948 (C57BL/6J). This strain was transmitted at the 32th generation (F32) from the Jackson Laboratory to the National Institut of Health (N.I.H) in 1951 (C57BL/6N).

The C57BL/6N mouse shares many characteristics with the C57BL/6J, e.g. alopecia and cannibalism. 5 SNP differences have however been identified (Petkov and Wiles, 2005). This strain does not have the deletion in the Nnt gene that has been found in the C57BL/6J. It can thus be used as a control in metabolic studies that focus on the mechanisms of glucose tolerance, e.g. Diet-Induced-Obesity studies.

The C57BL/6N mouse is homozygous for the Crb1rd8 gene (retinal degeneration 8 mutation). It’s characterized by multiple spots, caused by retinal folds and pseudorosettes with large white retinal deposits covering the inferior quadrant of the retina, found in the fundus of the eye (Aleman, 2011; Chang et al. 2002).

Due to its good breeding performance, this strain is used in the production of embryos for transgenesis (QUICKBLASTO®). The QUICKBLASTO®, a JANVIER LABS's product, is a kit containing straws of frozen embryos at the morula stage (C57BL/6NRj or BALB/cAnNRj). With these embryos, after thawing and culture, you will have blastocysts ready to receive your embryonic stem cells.

Our added value

  • The « JANVIER LABS Genetic Policy », a specific programme, guarantees homozygosity of autosomal pairs.
  • Animals with the SPF or SOPF standards.
  • A gentling policy for docile and easy-to-handle animals.
  • Optimal stability conditions of our models during shipments, thanks to our dedicated and internal transport service.
  • A scientific support with a team of Veterinarians and PhD.

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