Research models

List of models

Nomenclature: FVB/NRj

Type: Inbred mouse
Colour and related genotype: Albino mouse, Tyrc/Tyrc, A/A - MHC: Haplotype H2q
Origin: National Institutes of Health (USA) - 1996
Breeding: Good breeder, aggressive male, moderate growth

Fields of research

  • Immunology
  • Oncology
  • Transgenesis

Description of our model

In 1966, 2 strains of NIH SWISS mice, HSFR/N and HSFS/N, were selected based on their resistance or sensitivity, respectively, to histamine following pertussis (whooping cough) vaccination.

At the 8th generation (in 1970), the presence of the Fv1b allele, which induces sensitivity to the B strain of the Friend murine leukemia virus, was highlighted in the HSFS/N strain. Mice homozygous for this allele were inbred thus creating the FVB/N strain. The presence of large pronuclei in the embryos, which helps micro-injection and their large litters contribute to the suitability of the FVB/N strain for transgenesis. When compared to other inbred strains, FVB/N‘s respiratory system is sensitive to asthma with an important production of antigen-specific IgE antibodies. Its H2q MHC haplotype non-withstanding, FVB/N mice are resistant to the induction of arthritis by collagen injection.

FVB/N mice are very active and develop a mild hyperthermia under stress. The FVB/N strain does not develop spontaneous tumours and shows a certain resistance to the chemical induction of papillomas, which, when they do appear, most of the time progress to carcinomas. This strain is homozygous for the Pde6brd1 allele which leads to retinal degeneration.

Our added value

  • The « JANVIER LABS Genetic Policy », a specific programme, guarantees homozygosity of autosomal pairs.
  • Animals with the SPF or SOPF standards.
  • A gentling policy for docile and easy-to-handle animals.
  • Optimal stability conditions of our models during shipments, thanks to our dedicated and internal transport service.
  • A scientific support with a team of Veterinarians and PhD.

Download the corresponding health monitoring reports

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