Research models

List of models

Aged C57BL/6JRj
Nomenclature: C57BL/6JRj

Type: Inbred mouse
Colour and related genotype: Black mouse,a (a/a) non agouti - MHC: Haplotype H2b
Origin: CSAL (Orleans) - 1993 (F172)
Breeding: Good breeder but quite difficult to rear (sensitive to the environment). Cannibalism with its pups.

Fields of research

  • Cardiovascular research: atherosclerosis
  • Development biology, ageing
  • Immunology and inflammation
  • Infections
  • Metabolism: obesity, diabetes, hyperglycemia, insulin resistance
  • Neurobiology and neuro-sensorial research
  • Oncology
  • Genetic background for transgenic animals production
  • Toxicology, hematology

Description of our model

This strain was created by C.C. LITTLE, in 1921, from Miss Abbie LATHROP’s stock. The Jackson Laboratory’s colony was divided in two sub-strains before 1937, resulting in the C57BL/6 and the C57BL/10 strains. The C57BL/6 strain was brought to The Jackson Laboratory in 1948 (C57BL/6J).

C57BL/6JRj show age-related hearing loss and are resistant to audiogenic seizures. This hearing loss is related to the presence of allele Cdh23ahl(Cadherin 23 age-related hearing loss). It’s a recessive mutation of the Cdh23 gene (chromosome 10) that results in progressive hearing loss starting at 10 months of age. This strain is sensitive to Diet-Induced Type II diabetes and atherosclerosis.

C57BL/6JRj are active and relatively aggressive but easy to manipulate and have a long life expectancy (2 years). They have a low incidence of tumours which make it a prime model for ageing studies.

JANVIER LABS’s aged C57BL/6JRj mice are males selected at weaning and kept solely for ageing. They are kept in their original barrier rooms until 24 months of age in a controlled environment and health status.

Important notices: These animals have never been used as breeders.

C57BL/6JRj carry a deletion in the Nnt gene (arose in the C57BL/6J prior to 1984).

Our added value

  • The « JANVIER LABS Genetic Policy », a specific programme, guarantees homozygosity of autosomal pairs.
  • Animals with the SPF or SOPF standards.
  • A gentling policy for docile and easy-to-handle animals.
  • Optimal stability conditions of our models during shipments, thanks to our dedicated and internal transport service.
  • A scientific support with a team of Veterinarians and PhD.

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