Research models

List of models

Nomenclature: NOD.CB17/Prkdcscid/scid/Rj

Type: Mutant congenic mouse
Colour and related genotype: Albino mouse, Tyrc/Tyrc - MHC: Haplotype H2g7
Origin: INSERM Saint Vincent de Paul - (Paris, France, via CDTA, Orléans) - 2010
Breeding: Animal easy to rear, strong maternal instinct, Mating scheme: homozygous ♂ x homozygous ♀

Fields of research

  • Experimental infections
  • Immunology
  • Inflammation
  • Monoclonal antibodies: study and production
  • Oncology
  • Transplantation: xenograft and allograft

Description of our model

The scid (Severe Combined Immunodeficiency) mutation was discovered in a colony of inbred BALB/c-Ighb (CB-17/Icr, BALB/c congenic background with Ighb-Cb allel from the C57BL/Ka strain) mice in 1980 by Dr. M.J. Bosma and his team, at the Fox Chase Cancer Center (Philadelphia, PA).

This recessive autosomal mutation impairs lymphoid differentiation. These mice are deficient in T and B cells but myelopoiesis is not affected. On a NOD background, antigen-presenting cells’ (APC), myeloid cells’ and the NK cell functions are impaired.

Most homozygotes do not have any detectable IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA.

Some NOD-prkdcscid mice can become "leaky" from the spontaneous development of functional T and B lymphocytes. The presence of the prkdcscid mutation does not allow for the phonotypical expression of the type I diabetes that characterizes the NOD background (Non Obese Diabetic).

NOD SCID mice survive under SOPF conditions for 8 to 9 months (before the development of thymic lymphoma).

Our added value

  • The « JANVIER LABS Genetic Policy », a specific programme, the homogeneity of the genetic background, identic to the wild types used as controls.
  • Animals with the SOPF standards.
  • A gentling policy for docile and easy-to-handle animals.
  • Optimal stability conditions of our models during shipments, thanks to our dedicated and internal transport service.
  • A scientific support with a team of Veterinarians and PhD.

Download the corresponding health monitoring reports

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