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Humanized models

The reference models for immunotherapeutics development

Accelerate your development program
with a humanized model

The rise of research to develop treatments in oncology, immunology and infectious diseases is leading to a rapid
increase in the demand for humanized mouse models. JANVIER LABS has developed the NXG-HIS mouse, a strain that
completes our range of fully characterized immunodeficient models, providing a predictive preclinical model, in
particular for the evaluation of immunotherapies.

The NXG-HIS mouse is a mouse model with a human immune system, here by treatment with Busulfan and
engraftment of human CD34 cells. This model is particularly relevant for preclinical studies, especially for the evaluation
of a multitude human molecules and innovative therapeutic targets.

Our humanized models

NXG, a perfect model for the humanization
of the immune system

The NXG original model for the creation of the NXG-HIS is a genetically modified strain (GEMM) obtained by
homologous recombination (IL2rg), in NOD fund and presenting the SCID mutation of interest.
The NXG mouse is a JANVIER LABS proprietary model, free to use and genetically characterized (its severe
immunodeficiency makes it a perfect model for the humanization of its immune system).

Janvier Labs supports you for your research in immunology and oncology

Get access to all our models

Janvier Labs provides a comprehensive range of all the available models. Make your research easier and save time to make your choice.

Download the catalog

Did you find your model?

Have your model created by our experts. We are working with the Center of Immunophenomics in Marseille to give access to a comprehensive and integrated offering, with options for characterization, cryopreservation and breeding to meet your requirements.

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