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Speed Congenics - Backcross

Specifications

Transferring a mutation from a genetic background to another.

The transmission of a mutation can be tested at each generation by measuring the % of genetic markers of a recipient strain (a panel of 2050 SNPs (mice) or of 740 SNPs (rats) is analysed and covers the whole autosomes with an average interval of 5Mb). The 2 highest results are used for the next generation.

Using this technique, over 5 generations, animals consist of more than 99.9% of the recipient genome.

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