Aged C57BL/6JRj Mouse

This strain was created by C.C. LITTLE, in 1921, from Miss Abbie LATHROP’s stock. The Jackson Laboratory’s colony was divided in two sub-strains before 1937, resulting in the C57BL/6 and the C57BL/10 strains. The C57BL/6 strain was brought to The Jackson Laboratory in 1948 (C57BL/6J).

C57BL/6JRj show age-related hearing loss and are resistant to audiogenic seizures. This hearing loss is related to the presence of allele Cdh23ahl (Cadherin 23 age-related hearing loss). It’s a recessive mutation of the Cdh23 gene (chromosome 10) that results in progressive hearing loss starting at 10 months of age. This strain is sensitive to Diet-Induced Type II diabetes and atherosclerosis.

C57BL/6JRj are active and relatively aggressive but easy to manipulate and have a long life expectancy (2 years). They have a low incidence of tumours which make it a prime model for ageing
studies.

JANVIER LABS’s aged C57BL/6JRj mice are males selected at weaning and kept solely for ageing. They are kept in their original barrier rooms until 24 months of age in a controlled environment and health status.

Main application and research fields