B6 Agouti Mouse

Model characteristics

Type:

Inbred mouse

Strain name:

B6(C)/Rj-A/A

Origin:

Created by JANVIER LABS in 2015, principle pair F0/N11

Colour and related genotype:

Agouti mouse - A/A

Breeding:

Good breeder

Cryo

In vivo

In vitro

Description of our model and application areas

This strain was developed by crossing a C57BL/6NRj with a BALB/cAnNRj and the B6cF1 (carrier of the Tyrmut gene) was backcrossed over 10 generations with a C57BL/6NRj genetic background. The result: an inbred mouse with a C57BL/6NRj genetic background and agouti colouring.

The B6(C)/Rj-A/A, therefore, has an agouti fur. This strain also possesses characteristics similar to a C57BL/6NRj, but does not carry the Nnt gene mutation, unlike the C57BL/6JRj.

The B6(C)/Rj-A/A is mainly used in transgenics for the creation of blastocysts intended for the reception of genetically modified ES cells by way of microinjection on mice with a C57BL/6 genetic background.
This strain can also be used in immunology research, such as C57BL/6.

It is, in this case, used in the production of embryo kits, from zygotes to blastocyst stage.