B6 hLAG3 Mouse
Immune Checkpoint Pathway
Model characteristics
Strain name:
C57BL/6N-Cd223tm3(CD223)/Rj
Type :
Humanized mouse
Origin:
Genotype & associated color
Black mouse
Performance de reproduction :
In vivo
Description of our model and application areas
Available model!
• Model expressing human LAG-3, instrumental in investigating immune exhaustion and cancer immunotherapy
• Crucial for understanding T cell dysfunction and regulatory T cell function
The replacement of the mouse Lag3 gene with its human ortholog enables the preclinical validation of anti-hLAG-3 compounds. Combined treatment with candidate anti-hLAG-3 compounds and Atezolizumab resulted in efficient tumor growth inhibition.
In vivo response of MC38 tumor-bearing humanized hLAG3 mice to combo-therapy.
Homozygous hLAG3 mice (n=8 per group) were inoculated with MC38 colon cancer cells. Randomization and treatment initiation were performed once the tumors grew to 70-80 mm3. A significant anti-tumor effect was observed when the antibody targeting human LAG3 was administered together with Tecentriq.
Research model catalog
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