B6 hTIGIT Mouse
Immune Checkpoint Pathway
Model characteristics
Strain name:
C57BL/6Smoc-Tigitem1(TIGIT)/SmocRj
Type :
Humanized mouse
Origin:
SMOC, 2024
Genotype & associated color
Black mouse
Performance de reproduction :
In vivo
Description of our model and application areas
The replacement of the mouse Tigit gene with its human ortholog enables the preclinical validation of compounds targeting human TIGIT.
B6 hTIGIT mice transplanted with Hepa1-6 liver cancer cells efficiently responded to Tiragolumab.
Homozygous hTIGIT mice were inoculated with Hepa1-6 cells. Randomization and treatment initiation were performed once the tumors grew to 110 mm3
Research model catalog
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