LEWIS Rat
Model characteristics
Type:
Inbred rat
Strain name:
LEW/OrlRj
Origin:
CSAL (Orléans) - 1987
Colour and related genotype:
Albino rat, a/a, B/B, Tyrc/Tyrc, h/h - MHC: RT1l Erythrocyte antigens: RT2a RT3a - Lymphocyte antigens: RT6a RT7a
Breeding:
High level of sterility, easy to rear, easy to handle
Cryo
In vivo
In vitro
Description of our model and application areas
The strain was created by Dr M. LEWIS from WISTAR stock. It was then transferred to APTEKMAN and BOGDEN in 1954 at F20, and then to SILVERS in 1958 at F31. It was used as background in many congenic strains (STARK and KREN, 1969).
LEWIS rat is highly sensitive to the induction of auto-immune disease, such as Experimental Autoimmune Encephalomyelitis (EAE), induced arthritis, glomerulonephritis and experimental myocarditis.
LEWIS rat is also sensitive to Diet-induced obesity and diabetes and streptozocin-induced diabetes.
Main application and research fields
Growth curve
The growth curve represents an average which reflects the weight variation of the strain measured between 21 and 84 days for males and females.
Biochemical and hematological parameters
of 10-week old LEWIS LEW/OrlRj rats
Reproductive data
Monogamous mating
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