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NMRI-nu Immunodeficient Mouse

Immunodeficient mouse for immunology and oncology research

Model characteristics

Type:

Mutant immunodeficient mouse

Strain name:

Rj:NMRI-Foxn1nu/nu


Origin:

CSAL (Orléans) - 1979

Colour and related genotype:

Albinos mouse - Tyrc/Tyrc

Breeding:


Cryo
In vivo
In vitro

Description of our model and application areas

The mutation appeared in 1962 in an outbred albino mouse stock at the Ruchill Hospital, Glasgow.

The mutation was transferred by Dr. Rygaard on the NMRI outbred strain for its better viability and fertility.

This mutation, identified by Dr. Grist, is an autosomal recessive one and arises in the Foxn1 (Forkhead box N1) gene (chromosome 11). It causes thymic aplasia (total or partial) which results in immunodeficiency. This results in a lack of T cells; B cells remain functional.

This mutation also leads to a keratinisation defect of the hair follicle and the epidermis. This results in mice with transient downy hair that, when it is gone, leads to an almost total absence of hair.

There is no link between the presence of down and immunodeficiency severity.

Main application and research fields

Immunology Oncology Physiology - Physiopathology Preclinical Transgenesis

Growth curve

The growth curve represents an average which reflects the weight variation of the strain measured between 21 and 77 days for males and females.

Haematological parameters

Flow cytometry analysis, spleen

All lymphoid organs of our models were analysed

Phenotypic characterisation

This model has been entirely characterized. The immunological and hematological parameters were characterized by Center of Immunophenomics (Ciphe, Marseille, France).

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