NMRI-nu Immunodeficient Mouse
Immunodeficient mouse for immunology and oncology research
Mutant immunodeficient mouse
CSAL (Orléans) - 1979
Colour and related genotype:
Albinos mouse - Tyrc/Tyrc
Description of our model and application areas
The mutation appeared in 1962 in an outbred albino mouse stock at the Ruchill Hospital, Glasgow.
The mutation was transferred by Dr. Rygaard on the NMRI outbred strain for its better viability and fertility.
This mutation, identified by Dr. Grist, is an autosomal recessive one and arises in the Foxn1 (Forkhead box N1) gene (chromosome 11). It causes thymic aplasia (total or partial) which results in immunodeficiency. This results in a lack of T cells; B cells remain functional.
This mutation also leads to a keratinisation defect of the hair follicle and the epidermis. This results in mice with transient downy hair that, when it is gone, leads to an almost total absence of hair.
There is no link between the presence of down and immunodeficiency severity.
Main application and research fields
The growth curve represents an average which reflects the weight variation of the strain measured between 21 and 77 days for males and females.
Flow cytometry analysis, spleen
All lymphoid organs of our models were analysed
This model has been entirely characterized. The immunological and hematological parameters were characterized by Center of Immunophenomics (Ciphe, Marseille, France).
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