B6 hCD28 Mouse
Immune Checkpoint Pathway
Model characteristics
Strain name:
C57BL/6N-Cd28tm1(CD28)/SmocRj
Type :
Knock-in humanized mouse
Origin:
SMOC, 2024
Genotype & associated color
Black mouse
Performance de reproduction :
In vivo
Description of our model and application areas
Available model!
• Model expressing human CD28, crucial for studying T cell co-stimulation and immune activation
• Essential in CAR-T therapy development and enhancing antitumor immunity
The B6 hCD28 mouse has been modified to replace the mouse Cd28 gene with the human ortholog. These mice show a similar distribution of immune cells as wild-type (WT) mice. Additionally, cytokine release was observed in T cells treated with TGN1412 ex vivo, demonstrating that this model is suitable for preclinical studies on efficacy and safety.
Secretion of IL-2 upon stimulation of T cells with TGN1412 compound or candidate compound.
Research model catalog
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