B6 hPD-1/hCTLA-4 Mouse
Immune Checkpoint Pathway
Model characteristics
Strain name:
C57BL/6Smoc-Pdcd1em1(PDCD1)-Ctla4em1(CTLA4)/SmocRj
Type :
Humanized mouse
Origin:
SMOC, 2024
Genotype & associated color
Black mouse
Performance de reproduction :
In vivo
Description of our model and application areas
The double humanized B6 hPD-1/hCTLA-4 mouse was created by crossbreeding the B6 hPD-1 and B6 hCTLA-4 mice.
In vivo response of MC38 tumor-bearing humanized hPD-1/hCTLA-4 mice to combo-therapy.
Homozygous hPD-1/hCTLA-4 mice (n=8 per group) were inoculated with MC38 colon cancer cells. Randomization and treatment initiation were performed once the tumors grew to 100 mm3. Combo-therapy with anti-hCTLA-4 Ipilimumab and anti-hPD-1 Nivolumab induced efficient tumor growth inhibition without affecting the animal body weight
Research model catalog
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