B6 hPD-1/hPD-L1 Mouse
Immune Checkpoint Pathway
Model characteristics
Type :
Humanized mouse
Strain name:
C57BL/6Smoc-Pdcd1em1(PDCD1)-Cd274em1(PD-L1)/SmocRj
Origin:
SMOC, 2024
Genotype & associated color
Black mouse
Performance de reproduction :
In vivo
Description of our model and application areas
The double humanized B6 hPD-1/hPD-L1 mouse was created by crossbreeding the B6 hPD-1 and B6 hPD-L1 mice.
In vivo response of MC38 tumor-bearing humanized hPD-1/hPD-L1 mice to combo-therapy.
Homozygous hPD-1/hPD-L1 mice (n=8 per group) were inoculated with MC38 colon cancer cells. Randomization and treatment initiation were performed once the tumors grew to 100 mm3. Both Atezolimumab and Nivolumab induced a significant tumor growth inhibition, with combo-therapy featuring improved response without affecting the body weight.
Research model catalog
〉