B6 hPD-L1/hCTLA-4 Mouse
Immune Checkpoint Pathway
Model characteristics
Strain name:
C57BL/6Smoc-Ctla4em1(CTLA4)-Cd274em1(CD274)/SmocRj
Type :
Inbred mutant mouse, GMO
Origin:
SMOC, 2024
Genotype & associated color
Black mouse
Performance de reproduction :
In vivo
Description of our model and application areas
The double humanized B6 hPD-L1/hCTLA-4 mouse was created by crossbreeding the B6 hPD-L1 and B6 hCTLA-4 mice. This model has been shown to effectively predict the anti-tumor effects of both single and combination therapies targeting hPD-L1 and hCTLA-4. Memory immunity was confirmed through a re-challenge experiment.
Research model catalog
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