B6 hTIM3 Mouse
Immune Checkpoint Pathway
Model characteristics
Strain name:
C57BL/6N-Havcr2em1(HAVCR2)/Rj
Type :
Humanized mouse
Origin:
Genotype & associated color
Black mouse
Performance de reproduction :
In vivo
Description of our model and application areas
Available model!
• Strain expressing human TIM-3, essential for studying T cell exhaustion and antitumor immunity
• Key in exploring checkpoint blockade therapy and cancer immunotherapy approaches
The replacement of the mouse Havcr2 gene with its human ortholog gene enables the preclinical validation of compounds targeting human TIM-3.
A low expression of TIM-3 was observed in naïve CD4- and CD8-positive T cells, which was successfully induced upon ex vivo stimulation. Expression of hTIM3 on blood and spleen myeloid cells was confirmed.
Research model catalog
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