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BLACK HOODED or PVG Rat

Model characteristics

Type:

Inbred rat

Strain name:

PVG/OrlRj

Origin:

Dr. HOEDEMAEUER (Gröningen - Netherlands) to Orleans in 1978

Colour and related genotype:

and white rat (black hooded), a/a, B/B, C/C, h/h - MHC: RT1^c

Breeding:

Easy to rear

Cryo

In vivo

In vitro

Description of our model and application areas

This strain was originally inbred by Glaxo, UK (1946). The stock originated from Kings College of Household Science and was then transferred to the Lister Institute and subsequently to VIROL, and to Glaxo in 1946 who started the BxS mating. It was then distributed to Agricultural Research Council, Cambridge. PVG means for Piebald Virol Glaxo.

PVG/OrlRj rats are resistant to Experimental Autoimmune Encephalomyelitis (EAE) and the induction of autoimmune thyroïditis. It is resistant to the development of glomerular sclerosis following unilateral nephrectomy. It is however moderately sensitive to the development of experimental glomerulonephritis following injection of nephritogenic antigen from bovine kidneys.

It is is susceptible to the development of mycobacterially induced adjuvent arthritis and to infection by Entamoeba histolytica.

There is a lower incidence of polyspermia than in WISTAR rats.