CBA Mouse
Model characteristics
Type:
Inbred mouse
Strain name:
CBA/JRj
Origin:
Zentralinstitut für Versuchstierzucht (Hannover) - 1988 (F200)
Colour and related genotype:
Agouti mouse, A/A - MHC: Haplotype H2k
Breeding:
Difficult to rear
Cryo
In vivo
In vitro
Description of our model and application areas
This CBA and its major substrains are known for their use in numerous research fields such as audition, immunology, gerontology, oncology or pharmacology. It has a few bristles on foot pads and some molars can be frequently be found absent.
The CBA is therefore broadly distributed, especially due its high spontaneous disease occurrence and its life-span going from 69 up to 117 weeks depending
on the substrain and sex. By crossing a DBA male with a Bagg albino female, Strong created the CBA in 1920. The descendants of this cross were both CBA and C3H. Starting from there, C3H were selected for their high mammary tumor incidence while the CBA were selected for their low tendency to develop a low incidence instead.
If the CBA has relatively good breeding performance (except for the N substrain) along with good litter sizes, it is not necessarily easy to breed.
Except for the mammary tissue, it has a high gross tumor rate and incidence, and when fed lipids at a high level, CBA tend to have a low propensity to atheroma.
Main application and research fields
Growth curve
The growth curve represents an average which reflects the weight variation of the strain measured between 21 and 84 days for males and females.
Reproductive data
Bigamous mating
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