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FVB Hairless mouse

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Model characteristics

Type:

Inbred mutant mouse

Strain name:

FVB/NRj-hrrh/rh


Origin:

Albino, naked skin (no fur), Tyrp1b (b/b, brown), Tyrc (c/c)

Colour and related genotype:

Breeding:

Difficult to breed


Cryo
In vivo
In vitro

Description of our model and application areas

Spontaneous hairless mutants have been observed and studied for more than a century and hairless mouse lines have been systematically
maintained in laboratories since the 1920’s. This strain created by the National Institute of Health (NIH, USA) in 1935, is believed that the hrrh mutation appeared few years ago, spontaneously becoming fixed in a hybrid strain (HOWARD, 1940) and then transferred to the FVB/N strain.
The other name Rhino FVB comes from the extremely thickened and wrinkled skin of this mutant which gives it a thick, wrinkled appearance comparable to rhinoceros.

The JANVIER LABS FVB/NRj-hrrh mouse strain received from Bomholtgaard (Ry, Denmark) in 1996 carries the rhino (hrrh) mutation which is the most severe manifestation of hairless mutations (MANN, 1971). This is the spontaneous recessive mutation of the hairless gene located on chromosome 14.

FVB hairless mice develop a normal coat up to 10 days of age, then they begin to lose hair, starting from the head, until they become naked and this at the age of 5 weeks. Some hairs may persist in a diffuse way. The claws become long and curved. Hyperkeratosis eventually appears in the most superficial layers of the stratified epithelium, especially around the hair follicles at around 2 weeks of age. Hyperkeratosis is very extensive and produces cysts, these are balls of keratin in the thickness of the skin that are produced in such large numbers that the surface of the skin increases considerably. The skin of the mice thickens and becomes wrinkled.

The development of the mammary glands is rudimentary. A high incidence of thymic lymphomas (benign tumors) is observed. The skin of this mouse is characterized by cyst formation, dilated sebaceous gland ducts, dermal inflammation and acanthosis and generalized orthokeratosis.

Despite their apparent resemblance to nude mice, FVB Hairless mice are perfectly immunocompetent.

Homozygous hairless females are generally infertile and have a shorter life expectancy (1 year on average).

Useful references
Topically applied Hsp90 inhibitor 17AAG inhibits UVR-induced cutaneous squamous cell carcinomas.
Singh ASingh ASand JMBauer SJHafeez BBMeske LVerma AK.
J Invest Dermatol. 2015 Apr;135(4):1098-1107. doi: 10.1038/jid.2014.460. Epub 2014 Oct 22.

Main application and research fields

Dermatology

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