B6 hSORT1 Mouse
GEM
Model characteristics
Strain name:
C57BL/6Smoc-Sort1em1(SORT1)/SmocRj
Type :
GEM
Origin:
SMOC 2026
Colour and related genotype
Black mouse
Performance de reproduction :
In vivo
Description of our model and application areas
B6 hSORT1
The B6 hSORT1 mouse expresses the human sortilin-1 receptor in place of the murine gene. Given SORT1’s involvement in lipoprotein metabolism and cardiovascular risk, this model enables evaluation of human-specific biologics and gene-targeting strategies.
It is particularly relevant for atherosclerosis, lipid homeostasis, and cardiometabolic drug discovery programs.
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