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OBESE Mouse

Metabolic mouse

Model characteristics

Type:

Strain name:

B6.V-Lepob/JRj


Origin:

Bom Holtgard (Denmark) - 1996

Colour and related genotype:

Obese black mouse, a/a, Lepob/Lepob
Non obese mouse (control): a/a, Lepob/+/+ or a/a, +/+

Breeding:

Good breeder, mating scheme: heterozygous ♂ x heterozygous ♀ (the homozygous mice are steriles)


Cryo
In vivo
In vitro

Description of our model and application areas

The ob mutation is a spontaneous autosomal recessive mutation on chromosome 6 (leptin gene), it appeared in the V/Le stock at The JACKSON LABORATORY in 1949. The mutation was propagated in the C57BL/6J inbred strain by backcrossing for more than 45 generations.

Homozygous mice are identifiable by their obesity at about 4-5 weeks of age. This obesity is characterized by hyperplasia and hypertrophy of adipocytes. It shows polyphagia, a Diabetic syndrome (type 2 diabetes) with hyperglycemia, hyperinsulinemia (increase in the number and size of the islets of Langerhans pancreatic cells β), insulin resistance, scar tissue formation defects, thermoregulation problems, hyperlipemia, increase in hormone production by pituitary and adrenal glands. This diabetic syndrome is genetic-background dependent. On a C57BL/6J background, hyperglycemia is mild and transient; it appears at around 1 month of age and disappears around 5 months of age.

Main application and research fields

Cardiovascular diseases Degenerative diseases, ageeing Immunology Metabolic disorders Physiology - Physiopathology

Useful documents

Download the technical sheet

picto télécharger

Health monitoring report

Growth curve

The growth curve represents an average which reflects the weight variation of the strain measured between 21 and 84 days for males and females.

Glucose and Insuline

Glucose and Insuline

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